产品详情介绍
干扰素-γ （Interferon-gamma，IFN-γ），也称为II型干扰素，是一种由自然杀伤细胞、活化的T细胞和某些其他免疫细胞产生的多功能细胞因子。IFN-γ在调节免疫反应、细胞生长、凋亡以及抗病毒和抗肿瘤活性中发挥着关键作用[1-2]。IFN-γ通过与其受体结合，激活特定的信号传导途径，可以增强免疫细胞的活性，包括巨噬细胞的活化和T细胞的增殖[3]。IFN-γ还能够增强细胞的抗病毒状态，抑制肿瘤细胞的生长，并通过促进CD95/Fas介导的凋亡过程来增强对肿瘤细胞的攻击[4-5]。
[1] Chen SN, Huang B, Zhang XW, Li Y, Zhao LJ, Li N, Gao Q, Nie P. IFN-γ and its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates. Dev Comp Immunol. 2013, 41(4):587-596.
[2] Mikulecký P, Cerný J, Biedermannová L, Petroková H, Kuchař M, Vondrášek J, Malý P, Šebo P, Schneider B. Increasing affinity of interferon-γ receptor 1 to interferon-γ by computer-aided design. Biomed Res Int. 2013.
[3] Chang YP, Chen CL, Chen SO, Lin YS, Tsai CC, Huang WC, Wang CY, Hsieh CY, Choi PC, Lin CF. Autophagy facilitates an IFN-γ response and signal transduction. Microbes Infect. 2011, 13(11):888-894.
[4] Giammarioli AM, Vona R, Gambardella L, Ascione B, Maselli A, Barbati C, Tinari A, Malorni W. Interferon-gamma bolsters CD95/Fas-mediated apoptosis of astroglioma cells. FEBS J. 2009, 276(20):5920-5935.
[5] Hu X, Ivashkiv LB. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity. 2009, 31(4):539-550.
