产品详情介绍
Activin A由两个抑制素β亚基通过二硫键连接组成同型二聚体，通过特定的受体激活细胞内的信号传导途径。Activin A在调控细胞的生长、分化、凋亡以及组织修复等多种生物学过程中起着关键作用[1]。Activin A通过与I型和II型激活素受体结合，激活SMAD依赖性信号通路，从而调节目标基因的表达。这一过程对于多种细胞功能和发育过程至关重要[2-3]。Activin A参与了多种疾病的发病机制，包括某些癌症的发展、自身免疫性疾病的病理过程以及组织纤维等。Activin A的调节作用使其成为治疗策略中的潜在靶点，尤其是在促进伤口愈合、改善免疫功能以及抗癌治疗中 [4-6]。
[1] Massague J, Blain SW, Lo RS. TGFβ signaling in growth control, cancer, and heritable disorders. Cell. 2000 Apr 21;103(4):295-309.
[2] Chen Y G, Wang Q, Lin S L, et al. Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Experimental biology and medicine, 2006, 231(5): 534-544.
[3] Harrison C A, Gray P C, Vale W W, et al. Antagonists of activin signaling: mechanisms and potential biological applications. Trends in Endocrinology & Metabolism, 2005, 16(2): 73-78.
[4] Ghorbani-Dalini S, Azarpira N, Sangtarash M H, et al. Optimization of activin-A: a breakthrough in differentiation of human induced pluripotent stem cell into definitive endoderm. 3 Biotech, 2020, 10(5): 215.
[5] Mennen R H, Oldenburger M M, Piersma A H. Endoderm and mesoderm derivatives in embryonic stem cell differentiation and their use in developmental toxicity testing. Reproductive Toxicology, 2022, 107: 44-59.
[6] Ries A, Schelch K, Falch D, et al. Activin A: an emerging target for improving cancer treatment?. Expert Opinion on Therapeutic Targets, 2020, 24(10): 985-996.
