产品详情介绍
血小板源性生长因子（Platelet-Derived Growth Factor，PDGF）是一种在多种生理和病理过程中起重要作用的细胞因子。PDGF由两条不同的多肽链组成，通过二硫键连接成二聚体，这使PDGF具有三种形式的二聚体结构，即PDGF-AA，PDGF-BB及PDGF-AB[1-3]。这些二聚体通过与两种类型的受体（PDGFR-α和PDGFR-β）结合来激活细胞内信号传导途径。PDGF-BB主要由血小板、巨噬细胞和肥大细胞产生，尤其在损伤后由血小板分泌。PDGF-BB作为一种有效的促有丝分裂因子，能够促进细胞的增殖和血管生成。另外PDGF-BB在肿瘤的生长发育过程中起着重要的作用，它参与了肿瘤的血管生成，并且是肿瘤诊断和识别的重要生物标志物[4-5]。
[1] Ross R. Platelet-derived growth factor. Annu Rev Med, 1987, 38:71-79.
[2] Heldin CH. Platelet-derived growth factor--an introduction. Cytokine Growth Factor Rev, 2004, 15(4):195-196.
[3] Bowen-Pope DF, Raines EW. History of discovery: platelet-derived growth factor. Arterioscler Thromb Vasc Biol, 2011 , 31(11):2397-2401
[4] Xiang DN, Feng YF, Wang J, Zhang X, Shen JJ, Zou R, Yuan YZ. Platelet-derived growth factor-BB promotes proliferation and migration of retinal microvascular pericytes by up-regulating the expression of C-X-C chemokine receptor types 4. Exp Ther Med. 2019, 18(5):4022-4030.
[5] Pandey P, Khan F, Upadhyay T K, et al. New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies. Biomedicine & Pharmacotherapy, 2023, 161: 114491.
